Fibrinogen and D-dimer protein levels in patients with preeclampsia: a systematic review and meta-analysis.

ABSTRACT:

Introduction

Preeclampsia (PE) is a significant obstetric and global health concern associated with fetal growth restriction, poor placental perfusion, and maternal organ dysfunction. Early detection through simple, routine antenatal indicators is essential. This systematic review and meta-analysis assessed fibrinogen (FIB) and D-dimer (DD) levels in PE patients compared to normotensive pregnant women.

Methods

Relevant articles were systematically identified through comprehensive searches across multiple databases such as PubMed, Scopus, Embase, and Hinari. Utilizing Stata version 14.0, we employed a random-effects model to estimate the pooled standardized mean difference (SMD) along with their corresponding 95% confidence intervals (CIs). Heterogeneity was assessed using I<

SUBMITTER: Alemayehu E 

PROVIDER: S-EPMC12330166 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature