Health Utility Survival for Randomized Clinical Trials: Extensions and Statistical Properties.

ABSTRACT: Overall survival has been used as the primary endpoint for many randomized trials that aim to examine whether a new treatment is non-inferior to the standard treatment or placebo control. When a new treatment is indeed non-inferior in terms of survival, it may be important to assess other outcomes including health utility. However, analyzing health utility scores in a secondary analysis may have limited power since the primary objectives of the original study design may not include health utility. To comprehensively consider both survival and health utility, we developed a composite endpoint, HUS (Health Utility-adjusted Survival), which combines both survival and utility. HUS has been shown to be able to increase statistical power and potentially reduce the required sample size compared t

SUBMITTER: Deng Y 

PROVIDER: S-EPMC12330342 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature