Blood samples collected under anesthesia can be used as a source of non-diseased controls for immune-based assays.

ABSTRACT: Recruiting very young, healthy children to serve as age-matched controls in research presents substantial ethical and practical challenges. One potential approach to address this issue is to recruit healthy children who are referred for elective procedures under general anesthesia. As infants are typically anesthetized using volatile anesthetics before cannula insertion for additional drug administration, blood samples become readily accessible after the onset of drug-induced coma. However, since prolonged exposure to inhaled anesthetic agents is known to have immune-modulating effects that could affect their suitability as experimental controls, we aimed to investigate whether immune changes are also present in samples collected immediately after gas induction in children undergoing elect

SUBMITTER: Domingo-Vila C 

PROVIDER: S-EPMC12330393 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature