Tau-Clinical Mismatch Identifies Individuals with Co-Pathology and Predicts Clinical Trajectory.

ABSTRACT:

Importance

The heterogeneous course of Alzheimer's disease makes it difficult to predict individuals' cognitive trajectories, which is particularly important in the era of disease modifying therapy. Identifying individuals more likely to have co-pathology and differing disease courses using clinically practical tools remains a critical gap.

Objective

To evaluate tau-clinical mismatch for identifying resilient and vulnerable individuals and compare levels of co-pathology and clinical trajectories between groups.

Design setting and participants

Participants were selected from the Alzheimer's Disease Neuroimaging Initiative (ADNI, inclusion from 2005-2024), Penn Alzheimer's Disease Research Center Cohort (Penn-ADRC, inclusion from 2002-2025), and Penn Anti-amyloid Therap

SUBMITTER: Brown CA 

PROVIDER: S-EPMC12330401 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature