Utility of Polygenic Risk Scores in Families with Exceptional Longevity.

ABSTRACT:

Introduction

Polygenic risk scores (PRS) have been used to assess an individual's risk for various diseases, including Alzheimer's disease (AD). This study applied the PRS approach to a cohort of families ascertained for healthy aging, that have shown a reduced risk of AD. Using the SNPs identified as significantly associated with AD in the study by Kunkle and colleagues, we examined the utility of PRS for predicting AD risk in a cohort ascertained for familial healthy aging.

Methods

We restricted the study to US LLFS study participants who have been evaluated for AD and have available whole genome sequencing (WGS) data. AD diagnosis was based on consensus diagnosis, and for those without consensus diagnosis, we used the algorithm based on standardized memory scores. PRS wer

SUBMITTER: Xicota L 

PROVIDER: S-EPMC12330441 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature