Distinct characteristics of lymphoid and myeloid clonal hematopoiesis in World Trade Center first responders.

ABSTRACT: Clonal hematopoiesis of indeterminate potential (CHIP) represents the presence of clonal somatic mutations in blood cells in otherwise healthy individuals. While CHIP is known to increase risk for hematologic malignancies and cardiovascular disease, its association with airborne carcinogens remains largely unknown. We investigated CHIP mutations in 9/11 World Trade Center (WTC) disaster responders (n=350), who experienced substantial exposure to a complex mix of airborne carcinogens. Ultra-deep whole-exome sequencing at 250X was performed on banked blood samples. We characterized CHIP mutations and their associations with clinical factors (age, ancestry, gender, body mass index, cardiovascular disease, stroke), laboratory parameters (peripheral blood counts), mental and cognitive assessmen

SUBMITTER: Esai Selvan M 

PROVIDER: S-EPMC12330444 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature