Structural injuries are associated with better emotional wellbeing after traumatic brain injury.

ABSTRACT:

Background

Emotional disturbances are common after traumatic brain injury (TBI), yet the neuroanatomic basis of these sequalae remains unclear. We aimed to determine whether emotional wellbeing is associated with the extent and/or location of structural brain injury in individuals with chronic TBI.

Methods

We studied 188 adults with chronic (≥1 year post-injury) TBI enrolled in the multi-center Late Effects of TBI (LETBI) study. Participants underwent T1-weighted MRI to assess cortical lesion location and volume, and diffusion MRI to measure global mean white matter fractional anisotropy (FA), defined as the mean FA across 40 white matter tracts. The primary outcome was emotional wellbeing, measured as the RAND-36 emotional wellbeing subscale t score. To identify association

SUBMITTER: Snider SB 

PROVIDER: S-EPMC12330447 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature