Risk factors for West Nile neuroinvasive disease and mortality in the United States, 2013-2024.

ABSTRACT:

Importance

West Nile virus (WNV) is the leading mosquito-borne infection in the United States and can cause West Nile fever (WNF) or West Nile neuroinvasive disease (WNND), resulting in substantial morbidity and mortality. Contemporary risk factor analyses are needed to identify populations at increased risk for severe outcomes and target interventions accordingly.

Objective

To assess risk factors for WNND and mortality among adults with WNV infection using a large national cohort from federated real-world data.

Design

A retrospective cohort analysis from 2013-2024, consisting of de-identified electronic health record data from the TriNetX Research Network, including adult patients with an ICD-10 diagnosis consistent with WNV infection. Data were accessed from March 2

SUBMITTER: Judson SD 

PROVIDER: S-EPMC12330448 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature