Anti-TRIM72 Autoantibodies in Idiopathic Inflammatory Myopathies.

ABSTRACT:

Background and purpose-

Tripartite motif-containing protein 72 (TRIM72) mediates tissue-repair following injury in several organs, including muscle and lung. Autoantibodies directed against TRIM72 (anti-TRIM72) have been identified in patients with idiopathic inflammatory myopathies (IIM) and disrupt TRIM72 function in vitro. We hypothesized that IIM patients positive for anti-TRIM72 antibodies would have a more severe clinical phenotype.

Methods-

Sera from IIM patient (antisynthetase syndrome [ASyS], immune mediated necrotizing myopathy [IMNM], and dermatomyositis [DM]) and healthy controls (HC) were included. Anti-TRIM72 autoantibodies were tested using enzyme linked immunosorbent assay. Anti-TRIM72 testing was positive if value was >2 standard deviations above the

SUBMITTER: Krustev E 

PROVIDER: S-EPMC12330466 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature