Neuroinflammation distinguishes HLA haplotypes in progressive supranuclear palsy.

ABSTRACT:

Objectives

Progressive supranuclear palsy (PSP) is a neurodegenerative 4R tauopathy clinically presenting with atypical parkinsonism or cognitive behavioral changes and a relatively uniform neuropathology. We recently identified rare HLA haplotypes in PSP and now examine whether HLA haplotypes are associated with different cytopathological and clinical phenotypes.

Methods

Retrospective collection of clinical data and mapping of T and B cells, microglia, and phosphorylated-tau (p-Tau) cytopathologies in 32 PSP cases. Machine learning was used to analyze whether pathological variables and their ratios, or the sequence of clinical symptoms cluster or predict HLA haplotypes.

Results

Four groups were defined based on HLA haplotypes: i) 12 cases with the haplotype associate

SUBMITTER: Forrest SL 

PROVIDER: S-EPMC12330476 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature