Mild subcortical stroke induces widespread astrogliosis independent of microglia and age.

ABSTRACT: Ischemic stroke induces a plethora of pathophysiological changes, including neuroinflammation and chronic cerebrovascular dysfunction. In humans, even small, silent strokes can trigger these pathologies, which can spread to brain regions far beyond the infarct and persist chronically, ultimately worsening prognosis and increasing the risk for vascular dementia and Alzheimer's disease. The cause of this extensive pathology is unknown, but reactive astrocytes and microglia are likely contributors. Here, we describe an optimized short-duration middle cerebral artery occlusion model that produces a clinically relevant small stroke confined to subcortical regions, similar to most silent strokes in humans. We termed this model the mild subcortical infarct (MSCI). We then mapped the spatiotempora

SUBMITTER: Stackhouse TL 

PROVIDER: S-EPMC12330495 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature