Segmental copy number amplifications are stable in the absence of selection.

ABSTRACT: Copy number variants (CNVs) are duplications and deletions of DNA sequences that contribute to genetic variation between individuals and underlie rapid adaptive evolution. Increases in gene copy number can confer a strong selective advantage in some circumstances, but CNVs can also incur fitness costs. Prior research has shown that experimental evolution of Saccharomyces cerevisiae in nutrient-limited chemostats recurrently selects for amplifications of nutrient transporter genes, including GAP1, MEP2, and PUT4 in glutamine, ammonium and proline limited conditions, respectively. However, the fate of these CNVs upon return of the organism to a non-selective environment, is unknown. To investigate the fitness costs and stability of CNVs upon reversal of the origin

SUBMITTER: De T 

PROVIDER: S-EPMC12330549 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature