Bidirectional Crosstalk Between Sleep and Pulmonary Arterial Hypertension.

ABSTRACT:

Background

Pulmonary Arterial Hypertension (PAH) is a devastating cardiopulmonary disease characterized by pulmonary vascular remodeling due to vascular cells dysfunction. Among other clinical signs, emerging data suggest poor sleep quality in patients with PAH; however, how poor sleep impacts hemodynamic burden, symptom severity, and pulmonary vascular remodeling during PAH progression remains unknown.

Methods

We used two models of sleep disturbances (sleep fragmentation and chronic jet lag) and different mouse models of PAH to determine the effects of poor sleep on PAH. We carried out timepoint quantitative RT-PCR analyses to define the clock gene oscillations in human pulmonary artery smooth muscle cells (PASMCs) isolated from non-PAH and PAH patients. Bulk RNA-sequencing

SUBMITTER: Imani S 

PROVIDER: S-EPMC12330576 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature