Hippocampal input-driven plasticity of prefrontal interneurons reveals a circuit basis for impaired spatial working memory.

ABSTRACT: Dynamic functional connectivity between the ventral hippocampus (vHPC) and medial prefrontal cortex (mPFC) is essential for spatial working memory (SWM). Interactions between vHPC projections and mPFC interneurons, and their plasticity, are uniquely positioned to influence SWM, yet the nature of these interactions remains unclear. Here, we combined in vivo optical stimulation of vHPC inputs to mPFC with calcium recordings of discrete mPFC interneuron populations in mice, revealing class-specific response profiles and plasticity. Repeated vHPC input stimulation persistently depressed activity in vasoactive intestinal peptide (VIP)-expressing interneurons and potentiated activity in somatostatin-expressing interneurons. Ex vivo whole-cell electrophysiology and computational mod

SUBMITTER: Silverstein SE 

PROVIDER: S-EPMC12330631 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature