Depot-Specific Roles for C/EBPα in White Adipose Tissue Development and Metabolism.

ABSTRACT: Rates of obesity and its associated metabolic comorbidities continue to rise in the developed world. It is well established that in obesity, the distribution and not just amount of excess white adipose tissue (WAT) correlates with a person's risk for comorbidities such as coronary artery disease and type 2 diabetes. Thus, understanding the specific mechanisms that drive WAT development in specific adipose depots could elucidate novel mechanisms of metabolic disease. SNPs near the gene CEBPA have been associated with multiple cardiometabolic traits by human genome-wide association studies, including waist-to-hip ratio, suggesting that CEBPA regulates WAT distribution. CEBPA encodes a well characterized transcription factor (C/EBPα) that is long recognized as a master re

SUBMITTER: Hu KY 

PROVIDER: S-EPMC12330668 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature