A Simultaneous Inhibition of ID1 and ID3 Protects Against Pulmonary Fibrosis.

ABSTRACT:

Background

Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease for which novel therapeutic approaches are desperately needed. Inhibitor of DNA binding (ID) proteins are regulated by Transforming Growth Factor-b. However, the regulation and the effects of ID proteins in IPF remain poorly understood. We aimed to assess the expression of ID proteins in IPF and determine the effects of ID proteins on human lung fibroblasts (HLF) in vitro and pulmonary fibrosis in vivo.

Methods

The expression of ID proteins in lungs and lung fibroblasts from mice and human patients with pulmonary fibrosis was evaluated. The effects of ID1/ID3 inhibition and overexpression on HLF were assessed. Genetic and pharmacological approaches were used in vivo to determine the r

SUBMITTER: Antar SA 

PROVIDER: S-EPMC12330687 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature