Adrenergic signaling coordinates distant and local responses to amputation in axolotl.

ABSTRACT: Many species regenerate lost body parts following amputation. Most limb regeneration research has focused on the immediate injury site. Meanwhile, body-wide injury responses remain largely unexplored but may be critical for regeneration. Here, we discovered a role for the sympathetic nervous system in stimulating a body-wide stem cell activation response to amputation that drives enhanced limb regeneration in axolotls. This response is mediated by adrenergic signaling, which coordinates distant cellular activation responses via the α_2A-adrenergic receptor, and local regeneration responses via β-adrenergic receptors. Both α_2A- and β-adrenergic signaling act upstream of mTOR signaling. Notably, systemically-activated axolotls regenerate limbs faster than naïve animals,

SUBMITTER: Payzin-Dogru D 

PROVIDER: S-EPMC12330692 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature