Environmental and Maternal Imprints on Infant Gut Metabolic Programming.

ABSTRACT: Early life is a critical period for immune and metabolic programming, but developmental patterns remain underexplored in populations from low- and middle-income countries. Here, we profiled the microbiome and metabolome of 55 Bangladeshi mother-infant dyads over the first six months of life. Importantly, we observed an increase in microbially-derived bile amidates and N-acyl lipids with age in conjunction with reads matching the bile salt hydrolase/transferase (bsh) gene. While microbial source tracking confirmed maternal fecal seeding, a substantial environmental contribution was also highlighted. Differences in infant fecal metabolic profiles were associated with delivery mode, maternal milk composition, household assets, and household-level water treatment. C-section deliv

SUBMITTER: Kvitne KE 

PROVIDER: S-EPMC12330730 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature