Acute EtOH enhances septohippocampal coordination but disrupts intrinsic hippocampal theta dynamics during foraging.

ABSTRACT: Theta oscillations - rhythmic patterns of synchronous activity within discrete brain regions - are known to support memory, navigation, and behavioral coordination, and are sensitive to pharmacological manipulation. Acute ethanol (EtOH) exposure has been shown to alter theta oscillations, but its effects on transient theta bursts and cross-regional coordination during naturalistic behavior remain unclear. We recorded local field potentials (LFPs) from the medial septum (MS), hippocampal Cornu Ammonis 1 (CA1), and medial prefrontal cortex (mPFC) in freely foraging mice following intraperitoneal injection of EtOH (1.5 g/kg) or saline. We analyzed spectral power, theta burst dynamics, phase, and lag timing. Burst features from CA1 were used to train a machine learning classifier to pre

SUBMITTER: Darden CB 

PROVIDER: S-EPMC12330758 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature