Bacterial metabolites induce cell wall remodeling, antifungal resistance, and immune recognition of commensal fungi.

ABSTRACT: The fungus Candida albicans commensally colonizes mucosal surfaces in healthy individuals but can cause both superficial mucosal and life-threatening disseminated infections. The balance between commensalism and pathogenicity is complex and depends on factors including host and fungal genetic background, the host environment, and fungal interactions with local microbes. The major interaction interface of C. albicans with the host is its multilayered cell wall, which is dynamic and highly responsive to the surrounding environment. Therefore, factors that influence the fungal cell wall will directly impact C. albicans-host interactions. Our work demonstrates that multiple physiologically-relevant gastrointestinal bacteria influence fungal cell wall composition during co-

SUBMITTER: Davis FA 

PROVIDER: S-EPMC12330762 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature