Distinct neurogenic pathways shape the diversification and mosaic organization of cortical output channels.

ABSTRACT: A hallmark of the mammalian cerebral cortex is its vast and diverse efferent projections across cortical areas mediated by extratelencephalic (ET) neurons that broadcast to myriad subcortical regions. ET neurons are generated from two fundamentally distinct neurogenic pathways: direct neurogenesis (dNG-ET^d) from radial glia progenitors and indirect neurogenesis (iNG-ETⁱ) from intermediate progenitors, but the contribution of ET^d and ETⁱ to the organization of cortical output channels is unknown. Leveraging a novel lineage-based genetic strategy enabling differential viral access to ET^d and ETⁱ in the same mouse, we show that iNG-ETⁱ massively amplifies and diversifies dNG-ET^d across the cortex. While ET

SUBMITTER: Suryanarayana SM 

PROVIDER: S-EPMC12330770 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature