The Longitudinal Association Between Chronic Back Pain and Cognitive Decline in Older Adults With Mediation Analysis: An Analysis of Four Population-Based Databases.

ABSTRACT:

Background

While studies suggest chronic back pain (CBP) may heighten accelerated cognitive decline risk in older adults, no multinational research has comprehensively examined this significant public health concern alongside healthy lifestyles' potential impact.

Methods

Data from 18,558 individuals across 17 countries (China, England, Europe, USA) were extracted from four databases (2010-2023; median follow-up: 8.4 years). Associations between CBP and memory-related diseases (MDs), cognitive function performance metrics (e.g., numeracy, orientation, immediate word recall, delayed word recall memory, and an overall cognitive score combining these elements), and subjective cognitive decline (SCD) were analysed using linear mixed-effects models and conducting mediation analysi

SUBMITTER: Huang FF 

PROVIDER: S-EPMC12330781 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature