Exact linear theory of perturbation response in a space- and feature-dependent cortical circuit model.

ABSTRACT: What are the principles that govern the responses of cortical networks to their inputs and the emergence of these responses from recurrent connectivity? Recent experiments have probed these questions by measuring cortical responses to two-photon optogenetic perturbations of single cells in the mouse primary visual cortex. A robust theoretical framework is needed to determine the implications of these responses for cortical recurrence. Here, we propose a formulation of the dependence of cell-type-specific connectivity on spatial distance that yields an exact analytic solution for the linear perturbation response of a model with multiple cell types and space- and feature-dependent connectivity. Importantly and unlike previous approaches, the solution is valid in regimes of strong as well as

SUBMITTER: Chau HY 

PROVIDER: S-EPMC12330895 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature