Diagnostic accuracy evaluation of a point-of-care antigen test for SARS-CoV-2 and influenza in UK primary care (RAPTOR-C19).

ABSTRACT:

Objectives

To evaluate the diagnostic accuracy of the Roche SARS-CoV-2 & Flu A/B Rapid Antigen Test at the point of care.

Design

Prospective diagnostic accuracy study.

Setting

17 primary care practices in England.

Participants

500 individuals with symptoms consistent with possible SARS-CoV-2 or influenza infection identified upon presentation to primary care or via medical note review.

Primary and secondary outcome measures

Sensitivity, specificity and predictive values, compared to a laboratory reference standard of real-time reverse transcription PCR, using samples collected using a combined nasal and oropharyngeal swab.

Results

Of 481 participants with available index and reference test results, 5.6% (27/481) were reference standard-positive fo

SUBMITTER: Fanshawe TR 

PROVIDER: S-EPMC12331028 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature