Triethylamine inhibits influenza A virus infection and growth via mechanisms independent of viral neuraminidase and RNA-dependent RNA polymerase.

ABSTRACT: Triethylamine (Et3N) is a proton (H⁺) acceptor that is widely used in various industrial organic synthesis processes, including the production of pharmaceuticals, agrochemicals, and polymers. Inhalation of high Et3N concentrations can damage human respiratory tract and lungs. Given the compound's known reactivity and membrane-penetrating properties, we hypothesized that non-toxic concentrations of Et₃N may exert modulatory effects on virus-host interactions in epithelial cells. We thus investigated the anti-influenza activity of Et3N and found that it enhanced the viability of influenza A H1N1 and H3N2 virus-infected Madin-Darby canine kidney (MDCK) cells. Non-cytotoxic Et3N concentrations reduced the number of infected cells and suppressed influenza A virus nucleoprotein expression as wel

SUBMITTER: Shoji M 

PROVIDER: S-EPMC12331046 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature