Changes in the pulmonary surfactant in patients with mild to moderate COVID-19.

ABSTRACT:

Introduction

Changes in the pulmonary surfactant have been seen in severe COVID-19, but data on mild to moderate COVID-19 is scarce. The aim of this study was to explore the protein and phospholipid profiles in the small airways in patients with mild to moderate COVID-19.

Methods

29 cases with COVID-19 and 17 healthy controls were examined at baseline. 22 cases were re-examined at follow-up after recovery from COVID-19. Airwave oscillometry was performed and the biological material from the respiratory tract lining fluid was collected with the PExA (Particles in Exhaled Air) method. SOMAscan was used for the analysis of proteins, and liquid chromatography with tandem mass spectrometry (LC-MS/MS) for phospholipids.

Results

95 lipid species belonging to 8 lipid classes,

SUBMITTER: Kokelj S 

PROVIDER: S-EPMC12331066 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature