Variability of test parameters from mice of different age groups in published data sets.

ABSTRACT: The use of mice as animal models in biomedical research allows the standardization of genetic background, housing conditions as well as experimental protocols, which all affect phenotypic variability. In this study, the phenotypic variability of test parameters was analyzed in genetically identical mice of different age groups, i.e., early adults versus late adults. Therefore, published data sets of genetically identical mice of different age groups collected from the same investigator/ project were retrospectively analyzed. Morphological parameters, blood parameters and behavioral tests were analyzed which are predominantly used in biomedical research. The JaxKOMP project examined C57BL/6NJ mice with an age of 7-20 weeks and 66-81 weeks. Further substrains of C57BL/6N mice with an age of

SUBMITTER: Aigner B 

PROVIDER: S-EPMC12331085 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature