<i>Lacticaseibacillus rhamnosus</i> P118 enhances host tolerance to <i>Salmonella</i> infection by promoting microbe-derived indole metabolites.

ABSTRACT: Salmonella is one of the most common foodborne pathogens, resulting in inflammatory gastroenteritis and frequently accompanied by dysbiosis. Gut commensals, such as Lactobacillus species, have been proven to exhibit broad antibacterial activities and protect hosts against pathogenic infections. Here, Lacticaseibacillus rhamnosus strain P118, screened from 290 isolates recovered from fermented yogurts and healthy piglet intestines using traditional and Caenorhabditis elegans-infection screening strategies, exerts great probiotic properties. Notably, P118 and its supernatant exhibited great antibacterial activities and attenuated C. elegans susceptibility to Salmonella infection. We found that P118 protected mice against Salmonella lethal infe

SUBMITTER: Wang B 

PROVIDER: S-EPMC12331243 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature