Knockdown of ACC1 promotes migration and invasion of U251 glioma cells by epigenetically suppressing SDH.

ABSTRACT: Glioma is a common and aggressive malignant brain tumor. Despite advances in research, the mechanisms driving glioma initiation and progression remain incompletely understood. The present study aimed to assess the role of acetyl‑CoA carboxylase 1 (ACC1) in glioma, focusing on its mechanistic function in U251 cells and its clinical significance. ACC1 expression was first assessed in four glioma cell lines and then the effects on cellular functions were evaluated. Based on the finding that ACC1 knockdown altered the phenotype of U251 cells, potentially through modulation of succinate dehydrogenase (SDH) activity, further mechanistic assessments were performed. Finally, the association between ACC1 expression and patient prognosis was analyzed. The results demonstrated that ACC1 overexpressio

SUBMITTER: Wei X 

PROVIDER: S-EPMC12331297 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature