Advancing Real-World Evidence Through a Federated Health Data Network (EHDEN): Descriptive Study.

ABSTRACT:

Background

Real-world data (RWD) are increasingly used in health research and regulatory decision-making to assess the effectiveness, safety, and value of interventions in routine care. However, the heterogeneity of European health care systems, data capture methods, coding standards, and governance structures poses challenges for generating robust and reproducible real-world evidence. The European Health Data & Evidence Network (EHDEN) was established to address these challenges by building a large-scale federated data infrastructure that harmonizes RWD across Europe.

Objective

This study aims to describe the composition and characteristics of the databases harmonized within EHDEN as of September 2024. We seek to provide transparency regarding the types of RWD available and

SUBMITTER: Blacketer C 

PROVIDER: S-EPMC12331365 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature