Mechanistic Insights Into Qidan Yixin Decoction for Diabetic Cardiomyopathy via Macrophage Polarization.

ABSTRACT: Background: Diabetic cardiomyopathy (DCM) has a multifactorial etiology, and no specific treatment is available for its management. Qidan Yixin decoction (QDYXD) demonstrated encouraging clinical results in treating DCM; however, its underlying mechanics are yet unclear. Methods: Network pharmacology was applied to determine the active ingredients and targets of QDYXD. The GeneCards and GEO databases were used to retrieve genes associated with DCM and macrophage polarization. These targets were subjected to GO and KEGG enrichment analyses, immune infiltration study, and PPI network design. The core targets were further refined using SVM-RFE, LASSO, and random forest algorithms. Docking the core targets with the main active components followed. For experimental validation, rat

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12331402 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature