A Meta-Analysis of Magnetic Resonance Spectroscopy Studies on Glutamatergic Neurometabolite Levels in Major Depressive Disorder.

ABSTRACT: Glutamatergic neurometabolite dysregulation has recently garnered attention in the pathophysiology of major depressive disorder (MDD). However, studies have reported heterogeneous results for changes in neurometabolite levels across brain regions and whether these changes are related to antidepressant intervention. Herein, we performed a meta-analysis to investigate consistent findings by searching PubMed, Embase, MEDLINE, PsycINFO, and SinoMed from the start date of these databases to May 2023 (PROSPERO#CRD42023405205). Among the 2529 publications screened, 55 studies were included in the meta-analysis, with 1400 MDD patients and 1322 healthy controls. The results revealed significant decreases in Glx (glutamate + glutamine) in the anterior cingulate cortex (ACC) and prefrontal cortex (PF

SUBMITTER: Tao S 

PROVIDER: S-EPMC12331408 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature