The role of diet in moderating the relationship between symptoms of depression and brain amyloid load.

ABSTRACT:

Background

Healthy lifestyle factors, including diet, may affect brain amyloid beta (Aβ) load. This study examines dietary patterns as moderators of the relationships among symptoms of depression, anxiety, and brain Aβ load.

Method

A cross-sectional study of cognitively unimpaired older adults (n = 524) from the Australian Imaging, Biomarkers, and Lifestyle study assessed dietary patterns, depressive and anxiety symptoms, and brain Aβ load. Moderation and simple slope analyses were conducted.

Results

The Dietary Approaches to Stop Hypertension (DASH) diet moderated the relationship between depressive and anxiety symptoms and brain Aβ load. Higher symptoms were associated with greater Aβ load in individuals with lower DASH adherence. This effect was also observed for a

SUBMITTER: Al Shamsi HSS 

PROVIDER: S-EPMC12331443 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature