Increased Mesostriatal Intrinsic Connectivity Associated With Cue Exposure in Adult Cannabis Users: Preliminary Findings.

ABSTRACT: Cue-induced craving-the desire to use a drug triggered by exposure to cues associated with prior use-is a central mechanism in the development and maintenance of problematic substance use behaviours. Drug cues have the power to induce craving even in long-term abstinent individuals, which has led clinicians to advise patients to avoid the people, places and objects that are associated with their use. This preliminary study builds on prior behavioural research that demonstrates that exposure to multimodal drug cues can increase craving even after the drug cues are removed from the environment. We used a novel fMRI paradigm that combined multimodal cannabis cue-exposure with resting-state functional connectivity to examine positive and negative functional connectivity (i.e., correlations and

SUBMITTER: Kleinhans NM 

PROVIDER: S-EPMC12331521 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature