Association of non-traditional lipid indices with diabetes and insulin resistance in US adults: mediating effects of HOMA-IR and evidence from a national cohort.

ABSTRACT: Dyslipidemia, diabetes mellitus, and insulin resistance (IR) are intricately linked. In recent years, a series of novel lipid indices have emerged. Investigating their correlation with diabetes and IR is critical for early intervention. This study analyzed 19,780 National Health and Nutrition Examination Survey (NHANES) participants (1999-2020), examining the atherogenic index of plasma (AIP), Castelli risk index I (CRI-I) and II (CRI-II), estimated small dense LDL cholesterol (EsdLDL-C), non-HDL cholesterol-to-HDL cholesterol ratio (NHHR), and remnant cholesterol (RC). Covariates were selected via Boruta and LASSO regression. Multivariate logistic regression, restricted cubic splines, ROC, subgroup, and mediation analyses were employed, validated by sensitivity analyses. The prevalence of

SUBMITTER: Wang K 

PROVIDER: S-EPMC12331762 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature