Immunotherapies in neuromyelitis optica: Bayesian network meta-analysis.

ABSTRACT:

Background

There are numerous immunotherapies that are effective in preventing relapses in neuromyelitis optica spectrum disorder (NMO-SD). With head-to-head clinical trials between immunotherapies lacking, Bayesian network meta-analysis can be used to compare treatment interventions. Previous network meta-analyses have compared monoclonal antibodies but either not included newer complement inhibitors or earlier immunotherapies such as rituximab or tocilizumab.

Objective

To compare immunosuppressive treatments used in relapse prevention in NMO-SD.

Methods

PubMed, EMBASE and Scopus were searched for randomised controlled trials until 20th September, 2024. Search terms strategy included neuromyelitis optica, antibody and relapse. Randomised controlled trials testing imm

SUBMITTER: John N 

PROVIDER: S-EPMC12331795 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature