Validation and clinical correlates of the Turkish version of the methotrexate intolerance and severity assessment (MISA) questionnaire in rheumatoid arthritis.

ABSTRACT: The ''Methotrexate Intolerance and Severity Assessment in Adults'' (MISA) questionnaire was developed in patients with rheumatoid arthritis (RA) to better define methotrexate (MTX)- related intolerance. This study aims to translate and validate the MISA questionnaire in Turkish. A total of 130 RA patients who used MTX for at least three months were included in the study. The Turkish version of the MISA was developed following the recommended guidelines for cross-cultural adaptation. The validity of the test was assessed using Cronbach's α agreement. Test-retest reliability was tested with a 2-way random effect intra-class correlation coefficient (ICC). Intolerance by physician's decision was accepted as the gold standard. The Kappa test analyzed the agreement between intolerance according

SUBMITTER: Cinakli H 

PROVIDER: S-EPMC12331811 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature