Predictive clinical factors for the progression from idiopathic late-onset cerebellar ataxia to multiple system atrophy cerebellar type.

ABSTRACT:

Objectives

Patients initially diagnosed with idiopathic late-onset cerebellar ataxia (ILOCA) may develop multiple system atrophy cerebellar type (MSA-C). However, data on conversion time, associated clinical factors, and the role of the neurofilament light chain (NFL) in this process remain limited. This study aims to investigate the conversion from ILOCA to MSA-C and examine the associated factors and the predictive value of NFL.

Methods

This retrospective study included patients with ILOCA at the initial visit, recording the conversion to MSA-C and its duration. The median time to conversion was estimated using the Kaplan-Meier analysis. The roles of baseline orthostatic dizziness, rapid eye movement sleep behavior disorder (RBD), hot cross-bun sign, and urinary symptoms i

SUBMITTER: Lee S 

PROVIDER: S-EPMC12331855 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature