Comparative risk of retinal microvascular disorders in patients with gout initiating febuxostat versus allopurinol: a population-based cohort study.

ABSTRACT: Despite recent accumulation on cardiovascular (CV) safety data on xanthine oxidase inhibitors (XOIs) among gout patients, assessment has been largely limited to macro- than micro-vascular disorders, prompting the investigation on the latter outcome. Therefore, we aimed to compare the risk of retinal microvascular disorders between allopurinol and febuxostat initiators among gout patients. Using the 2011-2019 Korean National Health Insurance service database, we conducted a cohort study on gout patients initiating allopurinol or febuxostat. The primary outcome was a composite of retinal microvascular disorders. After 1:1 propensity-score (PS) matching in non-diabetic (non-DM) and diabetic (DM) subgroups, pooled and subgroup-specific hazard ratios (HRs) and 95% confidence intervals (CIs) wer

SUBMITTER: Kim MJ 

PROVIDER: S-EPMC12331893 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature