ZC3H13 mediates N6-methyladenosine modification of SNTB1 to promote epithelial-mesenchymal transition in gastric cancer.

ABSTRACT: Gastric cancer (GC) is one of the highly aggressive human malignant tumors. However, as one of the components of m6A methylation, ZC3H13 has not been reported to regulate the occurrence and development of GC. We determined the expression of ZC3H13 in GC and its correlation with prognosis using the TCGA and ACRG datasets. The effect of ZC3H13 on GC was elucidated through in vivo and in vitro assays. Next, we identified the downstream target of ZC3H13 via MeRIP-seq, and RNA-seq combined with multi-omics analysis, and explored the regulatory mechanism of ZC3H13 in GC using methods such as immunoprecipitation. We found that ZC3H13 is highly expressed in GC tissues and contributes to the poor prognosis of GC patients. ZC3H13 promoted the proliferation, invasion and migration of GC cells in vivo

SUBMITTER: Xie X 

PROVIDER: S-EPMC12331926 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature