Sex-based differences in cell migration on aligned topographies.

ABSTRACT: Sexual dimorphism has been observed in many physiological and pathological responses, yet few studies incorporate both female and male experimental groups for preclinical work. For the development of biomaterial devices, in vitro studies are essential for design and optimization, and quantitative comparison of female and male cell migratory behavior is a crucial design consideration. In this work, we thoroughly examined sex-based migration on flat controls and aligned nanofiber scaffolds of various diameters using anomalous and random walk models. Male and female cells exhibited significantly different migration on flat substrates, with female cells having increased speed while male cells had higher persistence. Persistence increased with the introduction of aligned fiber topography for fe

SUBMITTER: Hu Y 

PROVIDER: S-EPMC12331958 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature