A frame network study of first-episode schizophrenia, ultra-high risk, and healthy populations.

ABSTRACT: Schizophrenia is a complex neuropsychiatric disorder, and the abnormalities in brain networks during its early stages remain incompletely understood. Previously, we identified a stable high-intensity functional network, termed the "Frame Network," in healthy individuals and observed its aberrations in schizophrenia patients. This study aimed to utilize this network to explore disconnection abnormalities in early-stage schizophrenia. This study compared drug-naïve first-episode schizophrenia patients (FES, n = 83), ultra-high risk of schizophrenia (UHR, n = 65), and matched healthy controls (HC, n = 67). Frame networks were analyzed across groups, and differences were assessed using networks from healthy people (HP) derived from stable connections in two public datasets. Network-Based Stati

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC12331967 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature