No indications of weight gain associated DNA methylation changes in patients with anorexia nervosa.

ABSTRACT: Anorexia nervosa (AN) is a mental disorder marked by a significantly low body weight. Differentially methylated CpG sites have been reported to be involved in body weight regulation. Methylation pattern may change during considerable weight gain by in-patient treatment. Consequently, we aimed to (1) replicate the hypomethylation at the NR1H3 gene locus (identified in our previous epigenome-wide association study) in independent study groups of 189 female patients with AN and 67 healthy-lean female controls, and (2) identify regions associated with large weight gain associated DNA methylation changes in three patients with AN through whole-genome bisulfite sequencing in CD14⁺ cells. In the replication study, no evidence was observed for hypomethylation at the investigated 15 CpG

SUBMITTER: Rajcsanyi LS 

PROVIDER: S-EPMC12331989 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature