Modular architecture of K⁺ channels: the functional plasticity of the pore module.

ABSTRACT: Miniature K⁺ channel proteins from viruses (Kcv) are structurally and functionally equivalent to the pore module of all K⁺ channels. Here, we summarize data in support of the hypothesis that pores of primitive K⁺ channels served as building blocks for evolving the modern complex mammalian ion channels. Experimental data show that mutations in Kcv channels can generate gating phenomena like slow-activating inward or outward rectification, which are typical of complex mammalian channels. Hence, the basic mechanism for rectification is an inherent property of the pore module, which was further tuned and/or amplified during evolution by the addition of sensory protein domains. This evolutionary trend can be experimentally mimicked by coupling small pore units w

SUBMITTER: Rauh O 

PROVIDER: S-EPMC12332018 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature