NMN improves cardiac function in SIRT3 knockout mice via the SIRT1/PGC-1α pathway.

ABSTRACT: SIRT3 knockout mice develop cardiac insufficiency due to decreased mitochondrial function. However, upregulation of the NAD+/NADH ratio can compensate for SIRT3 deficiency through the SIRT1/PGC-1α pathway, thereby improving mitochondrial function. We therefore hypothesized that upregulation of SIRT1 expression could improve cardiac function in SIRT3 knockout mice through its interactive compensatory effect. We first determined that SIRT3 knockout mice would develop cardiac insufficiency at 8 weeks of age by ultrasound cardiac function testing, and then we selected 6-week-old SIRT3 knockout mice with similar body weights of both sexes and performed intraperitoneal injections of NMN over a 14-day period to increase the content of NAD + in the myocardial tissue of the mice. The results showed

SUBMITTER: Zhao X 

PROVIDER: S-EPMC12332049 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature