Metabolic profile changes in patients with rheumatoid arthritis detected using mass spectrometry.

ABSTRACT:

Background

Rheumatoid arthritis (RA) presents as pain, swelling and leads to irreversible damage in joint, and adversely affects the quality of life of patients with RA. However, the etiology of RA is still unclear, and novel biomarkers are demanded for the early prediction and diagnosis of RA and dissecting disease mechanisms.

Objective

This study aimed at profiling the disordered metabolic pathways in RA and selecting potential biomarkers to distinguish RA patients from healthy individuals, and systematically investigated the associations between metabolites and the risk of RA.

Methods

A total of 533 participants, including 382 healthy individuals and 151 RA patients, were recruited to explore altered metabolic profiles through the analysis of dried blood spot sampl

SUBMITTER: Wu X 

PROVIDER: S-EPMC12332061 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature