Metabolomics and network analysis reveal the mechanism of Salvia miltiorrhiza bunge extract in ameliorating cognitive dysfunction in sleep-deprived rats.

ABSTRACT: Sleep deprivation (SD) causes learning memory and cognitive impairment. Salvia miltiorrhiza Bunge (Danshen, DS), a medicinal plant in the family Labiatae, has been traditionally used for sleep-related disorders. Previous studies have shown that DS can ameliorate SD-induced cognitive impairment. However, the underlying mechanisms for its pharmacological effects remain unclear. This study aimed to evaluate the protective effects and mechanisms of DS extract against cognitive impairment in SD rats. UPLC-QTOF/MS was used to analyze DS extracts. The SD model was constructed utilizing a modified multi-platform aquatic sleep deprivation procedure that lasted 21 days. The Morris water maze test (MWM), hematoxylin and eosin (H&E) staining, and enzyme-linked immunosorbent assay (ELISA) were used to

SUBMITTER: Zhang M 

PROVIDER: S-EPMC12332084 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature