ITGAV as a promising diagnostic, immunological, and prognostic biomarker in pan-cancer.

ABSTRACT: Integrin αV (ITGAV) plays a key role in cell adhesion, migration, and immune regulation, and is implicated in tumor progression. However, its comprehensive expression profile and functional relevance across different cancers remain poorly understood. We conducted an integrative pan-cancer analysis of ITGAV using data from TCGA, GTEx, CCLE, and other public databases. Expression, diagnostic value (via ROC analysis), and prognostic significance (via Cox and Kaplan-Meier analyses of OS, DSS, PFS, and DFS) were assessed. We further explored ITGAV's correlation with immune cell infiltration and immune-related genes, its predictive role in immunotherapy response based on immunophenoscore (IPS), and its drug-binding potential through molecular docking. (1) ITGAV was significantly overexpressed in

SUBMITTER: Su H 

PROVIDER: S-EPMC12332088 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature