Urine sodium levels post-saline infusion in differentiating non-edematous hyponatremia.

ABSTRACT: Accurately distinguishing hypovolemic hyponatremia from the syndrome of inappropriate antidiuresis (SIAD) remains challenging due to limitations in traditional pre-saline infusion urine sodium measurements. This prospective cohort study at two Thai medical centers evaluated whether post-saline infusion urine sodium improves diagnostic accuracy. We enrolled 113 hospitalized adults with non-edematous hypotonic hyponatremia (serum sodium < 130 mmol/L). Asymptomatic patients received 500 mL of 0.9% saline, while symptomatic patients received 150 mL of 3% saline. Urine sodium was measured before and after infusion (Time 1). Diagnostic performance was assessed using AUC curves, with Youden's J statistic determining optimal cutoffs. Post-infusion urine sodium at Time 1 demonstrated superior accur

SUBMITTER: Chienwichai K 

PROVIDER: S-EPMC12332142 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature