The association between white blood cell count and relative risk of non-small cell lung cancer.

ABSTRACT:

Background

High abundance of eosinophils has been proved to associated with favorable disease progression in non-small cell lung cancer (NSCLC) in the previous observational studies, but the causal relationship remains unclear. It is also unclear whether white blood cell (WBC) counts are essential for the risk of NSCLC.

Methods

Using multiple methods of Mendelian randomization (MR), we assessed the causality of WBC count, particularly basophil, eosinophil, monocyte, lymphocyte, and neutrophil counts on the risk of NSCLC, which includes squamous carcinoma and adenocarcinoma. Single cell RNA-sequencing and RNA-sequencing analysis illustrate the underline mechanism of the causality and its biological effects.

Results

Univariable MR analysis indicated the protective effec

SUBMITTER: Yang X 

PROVIDER: S-EPMC12332170 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature